Science Signaling http://stke.sciencemag.org/ Science Signaling, the Signal Transduction Knowledge Environment American Association for the Advancement of Science Nancy Gough (mailto:ngough@aaas.org) Copyright 2008 American Association for the Advancement of Science 2008-12-24T09:47:47-05:00 en Science http://www.sciencemag.org/icons/banner/title.gif http://www.sciencemag.org [Editorial] Beyond Microarrays http://stke.sciencemag.org/cgi/content/abstract/1/51/eg11?rss=1 Studies of global changes in mRNA abundance may be less than insightful. Michael B. Yaffe [Perspective] Bursting into the Nucleus http://stke.sciencemag.org/cgi/content/abstract/1/51/pe54?rss=1 Calcium elicits bursts of nuclear localization of a yeast transcription factor, which may enable the coordinated activation of target genes. Gerald R. Crabtree and Isabella A. Graef [Perspective] Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways http://stke.sciencemag.org/cgi/content/abstract/1/51/pe55?rss=1 Understanding how IL-4 and IL-13 signaling differ could result in the development of better anti-inflammatory therapies. Marsha Wills-Karp and Fred D. Finkelman [Meeting Report] Regulatory T Cells: The Cunning Fox and Its Clinical Application http://stke.sciencemag.org/cgi/content/abstract/1/51/mr3?rss=1 A conference in Beijing, China focused on the biology of regulatory T cells and their potential uses in treating various diseases. David S. Game, Xuetao Cao, Shuiping Jiang [Review] Structure and Function of the Phosphothreonine-Specific FHA Domain http://stke.sciencemag.org/cgi/content/abstract/1/51/re12?rss=1 The forkhead-associated (FHA) domain binds specifically to phosphothreonine residues and possesses unique structural and functional features. Anjali Mahajan, Chunhua Yuan, Hyun Lee, Eric S.-W. Chen, Pei-Yu Wu, Ming-Daw Tsai [Research Article] Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages http://stke.sciencemag.org/cgi/content/abstract/1/51/ra17?rss=1 The ability of IL-4, but not IL-13, to efficiently activate IRS-2 leads to the expression of a subset of genes in alternatively activated macrophages. Nicola M. Heller, Xiulan Qi, Ilkka S. Junttila, Kari Ann Shirey, Stefanie N. Vogel, William E. Paul, Achsah D. Keegan [Research Article] mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α http://stke.sciencemag.org/cgi/content/abstract/1/51/ra18?rss=1 The scaffold protein muscle A kinase-anchoring protein (mAKAP) regulates the stability and localization of the transcription factor HIF-1α. Wei Wong, April S. Goehring, Michael S. Kapiloff, Lorene K. Langeberg, John D. Scott [Editors' Choice] Turning to the DARC Side http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/51/ec438?rss=1 The Duffy antigen receptor for chemokines promotes leukocyte migration. Database of Cell Signaling: Canonical Pathway http://stke.sciencemag.org/cgi/cm/stkecm;CMP_5533?rss=1 Wnt/β-catenin Pathway